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SolicitationAmendment 2

Protein ENGineering (PENG)

DEF ADVANCED RESEARCH PROJECTS AGCY

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Response status

Due in 45 days

Oct 19, 2026, 4:00 PM UTC

Responses remain open.

Posted
Aug 21, 2026
Archive date
Nov 18, 2026
SAM status
Active

Answer-first brief

What the source record says

  • DEF ADVANCED RESEARCH PROJECTS AGCY published this solicitation.
  • The notice uses NAICS 541714 (Research and Development in Biotechnology (except Nanobiotechnology)).

Procurement identity

Notice ID
8d7bb66b691a4def9e7efe4d4345bb7a
Solicitation
DARPA-PS-26-129
Base type
Solicitation
Version
2 of 2

Solicitation facts

Structured fields from the current SAM notice version. A dash means the source did not publish a value.

Notice type
Solicitation
Solicitation number
DARPA-PS-26-129
NAICS
541714 — Research and Development in Biotechnology (except Nanobiotechnology)
PSC
AC12 — NATIONAL DEFENSE R&D SERVICES; DEPARTMENT OF DEFENSE - MILITARY; APPLIED RESEARCH
Set-aside
—
Set-aside code
—
Posted
Aug 21, 2026
Responses due
Oct 19, 2026, 4:00 PM UTC
Archive date
Nov 18, 2026
Archive type
autocustom
Base type
Solicitation
Organization type
OFFICE
Benchmark category
—
Category confidence
—
Category source
—
Last seen
Sep 5, 2026

Buyer and place

Office hierarchy and place of performance as published.

Department
DEPT OF DEFENSE
Department code
—
Subagency
DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Subagency code
—
Office
DEF ADVANCED RESEARCH PROJECTS AGCY
Organization path
—
Organization path codes
—
Office address
ARLINGTON, VA, 222032114, USA
Place of performance
—
City code
—
State
—
State code
—
Postal code
—
Country
—

Points of contact

Contact details from the current notice version.

Notice description

Source text reproduced without an AI summary.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Comparable award range

Historical award values for work matched by the fixed rubric—not an estimate of this opportunity.

Low end (p25)$1,261,340
Median$2,456,609
High end (p75)$4,983,092
Comparable awards
15
Median
$2,456,609
Computed
Aug 24, 2026
Rubric
comparables@2026.08.1
Comparable award values describe completed contracts. They do not state the government's budget and are not a bid recommendation.

Comparable awards

The match score is decomposed so each comparison can be challenged.

AwardContractorValueAwardedScoreWhy it matched
FUNDAMENTAL MODELING OF DEFECTS AND MATERIAL INTERFACES FOR DEVICE PHYSICS IN RADIATION ENRXFF CONSULTING LLC$249,999.88Apr 30, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
STTR II - RAPID ADDITIVE MIRROR PROCESSES (RAMP) PHASE II ST-22.1A_PHII_STTR_AF22A-T002MORPHOPTIC, INC.$1,249,879.00Apr 8, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
RAPID RESILIENT REEFS FOR COASTAL DEFENSE (R3D)UNIVERSITY OF HAWAII$22,335,922.00Apr 16, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
PHASE II SBIR ROBUST OPERATIONAL ULTRA-HIGH THROUGHPUT CELL LINEAGE TRACKING FOR RAPID BIOBIFROST BIOSYSTEMS INC$2,968,910.00Mar 16, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
DARPA RESEARCH PROGRAMTHE CHARLES STARK DRAPER LABORATORY, INC.$7,213,748.00May 5, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
DARPA TRIAGE CHALLENGEBATTELLE MEMORIAL INSTITUTE$2,999,993.00Mar 9, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
DARPA TRIAGE CHALLENGEMICHIGAN TECHNOLOGICAL UNIVERSITY$1,747,579.00Mar 3, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
WASTE UPCYCLING FOR DEFENSE (WUD)PHYSICAL SCIENCES INC.$1,944,308.00Apr 20, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
ASSURED MICROBIAL PRESERVATION IN HARSH OR REMOTE AREASBATTELLE MEMORIAL INSTITUTE$3,230,474.00Mar 5, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
HERMESNEW YORK UNIVERSITY$5,567,298.00Apr 10, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
BIOLOGICAL UNDERSEA ENERGY (BLUE)UNIVERSITY OF MARYLAND, COLLEGE PARK$8,120,541.00Apr 10, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
RESEARCH AND DEVELOPMENTMAINSTREAM ENGINEERING CORP$1,295,721.00Apr 1, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
PI CHANGESOLVUS GLOBAL LLC$999,914.00Apr 14, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
RESEARCH AND DEVELOPMENTINNEOS LLC$999,736.00Mar 5, 202652Same product and service code (25), Same industry code (20), Recent enough to be relevant (7)
A-TEAM - OPERATIONS MANAGEMENTDCS CORPORATION$15,086,280.00Jul 18, 201946Same product and service code (25), Same industry code (20), Recent enough to be relevant (1)

Amendment history

A version is preserved whenever the normalized notice contents change.

VersionNotice typeObservedResponses dueContent hash
1SolicitationAug 23, 2026Oct 19, 2026, 4:00 PM UTC0442618e83168fb2
2SolicitationAug 28, 2026Oct 19, 2026, 4:00 PM UTC61aadb0928f41d2a

Record provenance

Field-level lineage for the current opportunity version.

FieldSourceSource as ofParserTransform
agency_nameSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
archive_dateSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
archive_typeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
base_typeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
contactsSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
descriptionSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
naics_codeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
notice_idSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
notice_typeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
office_citySAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
office_country_codeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
office_nameSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
office_postal_codeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
office_state_codeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
organization_typeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
posted_dateSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
psc_codeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
response_deadlineSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
sam_urlSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
solicitation_numberSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
subagency_nameSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
titleSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3
upstream_activeSAM.gov Contract OpportunitiesAug 23, 2026sam_opportunity_snapshot@2026.08.22026.08.3

Sources and method

Figures on this page are computed from public federal award records. Numbers are never estimated or generated; where a figure is withheld, the reason is stated rather than filled in.

Comparable awards are scored on benchmark category, product and service code, industry code, buyer, place, recency, and contract type. Rubric version comparables@2026.08.1.

  1. 1Notice fields come from the SAM.gov contract opportunities record last seen Sep 5, 2026. SAM.gov remains authoritative.
  2. 2Computed from 15 completed federal awards using comparables@2026.08.1, as of Aug 24, 2026. Award values are neither unit prices nor a forecast.

Note 1 covers the solicitation record; note 2 covers the comparable range. No synthetic FAQ or inferred solicitation value is published.

Protein ENGineering (PENG) — federal contract opportunity · BidBenchmark